Two more critical pieces have been added to the puzzle of how breakdowns in the extracellular matrix (ECM)--a mass of protein that serves as support "scaffolding" for cells--can lead to breast cancer. The pieces represent the findings of two separate but related studies conducted through a collaboration led by Mina Bissell, director of the Laboratory's Life Sciences Division (LSD), and Zena Werb, a professor with UC San Francisco's Laboratory of Radiobiology and Environmental Health.
In the first study, Bissell, Werb and colleagues demonstrated that uncontrolled production of metalloproteinase (MMP), an enzyme known to break down the ECM, can initiate the development of breast cancer. In the second study, the collaboration demonstrated that a breakdown of the ECM results in an abnormally high rate of apoptosis--programmed cell death--another significant factor in the development of breast cancer.
Breast cancer is the most common malignancy in women of the western hemisphere and accounts for the greatest number of deaths among western women between the ages of 40 to 45. It is estimated about five percent of all women in the United States will develop breast cancer.
About 15 years ago, working with tissue cultures, Bissell demonstrated that the ECM surrounding mammary epithelial cells in the breast plays a vital role in cell growth and development. This discovery led her to propose a direct link between the ECM and breast cancer, which occurs when cell growth and development runs amok. Since then, Bissell, working with other scientists at LBNL and elsewhere, has been steadily building up a picture of the interaction between breast cells and the ECM.
"If my hypothesis was correct, then a loss of ECM should destroy functional and morphological differentiation in cells," says Bissell. "We found this to be the case in tissue cultures, but we needed to show it was true in living organisms."
In addition to Bissell and Werb, the other participants in these studies were LSD's Nancy Boudreau, and Carolyn Sympson, a post-doc who was splitting her time between LBNL and UCSF. The research has been reported to the American Society for Cell Biology, and in the journal Science.
Since the ECM is so crucial to the overall development of an organism, its gene cannot simply be knocked out as is done with most other genes. Instead, the ECM must be studied through an indirect genetic route. In their collaborations, the Bissell-Werb team worked with mice that had been genetically engineered to produce an abundance of an MMP called stromelysin-1. Normally activated during pregnancy, this enzyme is an important regulator of milk production in the mammary gland. The research teams focused on the interactions between stromelysin-1 and a special type of ECM called "basement membrane" that specifically supports epithelial cells.
In the first study, the increased activity of stromelysin-1 destroyed the ECM and caused the mammary glands to lose function as if the mice were already involuting (returning to a pre-pregnancy state). The Bissell-Werb team found that 12 percent of these mice developed tumors similar to those formed in human breast cancer, whereas no tumors were found in the normal mice.
"We destroyed the ECM inappropriately and got inappropriate results," says Bissell. "This is what we would expect if the hypothesis is correct and the ECM is crucial to cell development."
The researchers suspected that the breakdown of ECM by stromelysin-1 triggers the development of genetic abnormalities in associated cells. As a followup, working first with tissue culture then with the same strain of stromelysin-1 producing mice, they investigated the effect that a breakdown of basement membrane ECM has on apoptosis in mammary epithelial cells.
Controlled death is as much a part of normal cell development and functioning as controlled growth and differentiation. If a cell does not die when it is supposed to, Bissell says, problems occur throughout the rest of the cycle that can lead to the development and spread of cancer.
In both the tissue culture and the mouse experiments, the Bissell-Werb collaboration found that the destruction of basement membrane ECM accelerated the rate of apoptosis in epithelial cells. Absent the ECM, apoptosis set in as much as 10 days earlier in the transgenic mice than in the normal mice.
"A cell can either differentiate, grow or die, depending on the signal sent to it by the ECM," says Bissell. "The ECM suppresses death by telling the cell to grow or differentiate instead. If we remove the ECM signals, then normal cells die without first doing what they are supposed to."
Investigating the mechanisms behind the ECM's regulation of apoptosis, the Bissell-Werb collaboration learned that the process revolves around the expression of a protein called the interleukin-1-beta converting enzyme (ICE). Apoptosis was induced by the activation of ICE which correlated with the loss of ECM. When ECM was present, the activity of ICE was inhibited and apoptosis did not occur. In normal breasts, ICE increases at the end of lactation. This leads to cell apoptosis and involution.
CAPTION -- Life Sciences Division Director Mina Bissell (left) and Zena Werb of UC San Francisco have added critical pieces to the understanding of breast cancer.
Photo by Paul Hames
The next phase in the Laboratory's identity transition will be to develop guidelines for use of the new name, as well as designs for official applications such as letterhead, business cards and publications. In the meantime, materials with "Lawrence Berkeley Laboratory" and "LBL" should continue to be used until supplies are exhausted and a new set of identifiers is adopted.
Currents will attempt to answer all initial questions regarding the new name in next week's (June 30) edition. Inquiries should be addressed to Ron Kolb, head for public communications, via e-mail or at M.S. 50A-4112.
Director Charles Shank has been selected as one of two national laboratory directors to serve as ex-officio members of the new Department of Energy Laboratory Operations Board.
The board, an outgrowth of the final report of the Task Force on Alternative Futures for the DOE national laboratories (the "Galvin Report"), was established to advise Energy Secretary Hazel O'Leary on strategic directions, budget and policy issues, and effective management of the laboratories.
According to its charter, the board "will assist the department in bringing sharpened focus to the mission of the laboratories and ensuing speedy resolution of issues and problems across the integrated laboratory system. The board will facilitate application of best business practices in management of the laboratories, including reduction of unnecessary and counterproductive management burdens on the laboratories, and will develop recommendations for the Secretary regarding changes in size, missions and scope of laboratory activities in light of changes in federal policy and funding."
The first meeting is scheduled for June 29 in Washington.
The board consists of 16 members, eight of them representing academia and industry. Among individuals already appointed are Richard Celeste, former governor of Ohio; Paul Fleury of Bell Labs; Edward Freiman; MRC Greenwood of UC Davis; Paul Gilman; and John McTague. These members will have staggered six-year terms and will collectively constitute a standing panel of the Secretary of Energy Advisory Board (SEAB).
The eight internal members were selected by the Secretary from among senior DOE management, including board chair and Undersecretary Charles Curtis. Others include Martha Krebs, director of the Office of Energy Research; assistant secretaries for Environment, Health and Safety, Defense Programs, Environmental Management, and Energy Efficiency and Renewable Energy; and the deputy undersecretary for Technology Partnerships.
Besides Shank, Sandia National Lab Director Al Narath and Secretary O'Leary are ex-officio members, along with the DOE General Counsel, two assistant secretaries and a rotating field office manager.
Subcommittees will be established to address specific issues. These include panels comprised of laboratory directors and programmatic deputies, and a subcommittee on management and research and development efficiency, of which Shank is also a member.
"This new board will serve a vital role in providing focused, regular attention to issues facing the Department's laboratory complex," O'Leary wrote in her memorandum establishing the board. "The fundamental priority of the Laboratory Operations Board will be to review and provide advice on efforts aimed at reducing the direct and indirect costs associated with management and supervision of the Department's laboratory system. The goal will be to assist the Department and its laboratories in securing higher levels of R&D performance at lower cost."
She added that she expects the board to provide at least semi-annual reports documenting accomplishments in the areas of cost containment, enhanced mission focus, and management efficiencies at DOE and within the laboratory system.
Campisi, who is acting head of the Department of Cancer Biology in the Life Sciences Division, is an advisor to both the National Institute on Aging and and National Cancer Institute. For the past 15 years, she has worked to understand how individual cells make decisions about whether to grow, differentiate, or stop dividing. That question is central to both cancer research and research on aging. Campisi will address the question of cell senescence and discuss what would happen if we could prevent our cells from aging. Could we actually extend our lifespan?
Lab employees, students, guests, and members of the public are invited to attend the summer lecture series. These non-technical presentations are held on Wednesdays at noon in the Bldg. 50 Auditorium. Bring your lunch! For further information, please contact the Public Information Department's Diane LaMacchia at [510] 486-4015.
June 28: Do Our Cells Have to Age?
Judy Campisi, Life Sciences Division
July 5: The Birth of the Universe
George Smoot, Physics Division
July 12: Alchemy with Computers: Predicting New Materials
Marvin Cohen, Materials Sciences Division
July 19: Parlez-vous Beams? Exploring Today's Accelerators
and Lasers
Swapan Chattopadhyay, Accelerator & Fusion Research Division
July 26: Groundwater Cleanup: Cost Effective Remedies
Sally Benson, Director, Earth Sciences Division
Once a year, I find it extremely useful to assemble our management team for concentrated discussions on strategic directions and programmatic focus. Seldom has such a conversation been more important to the future of the Laboratory than this year's, which took place May 21 through 23.
We exist in a national environment characterized by uncertainty--one in which the Department of Energy has been a target for reorganization or elimination, and budget cutters are threatening to chart a course that may de-emphasize the federal role in science. The national labs are challenged to reverse the trend and maintain our position of strength as the debate continues.
The Division Directors' retreat was designed to sharpen the focus of our mission and develop a tactical plan for the coming year. The 21 division directors and administrators engaged with me in a candid, spirited exchange of ideas and views that personified the strength of the Laboratory--a multidisciplinary mix of programs whose synergy, in cooperation and competition, energizes the whole. As we tried to define the individual qualities of each program, we realized that our true value lies in our interconnectedness, not just our individuality.
Invited guest Jim Decker, deputy director of DOE's Office of Energy Research, pointed out the difficulty of convincing Congress about the importance of fundamental research, and of the value of maintaining multi-program research laboratories in the DOE laboratory system. Therein lies our challenge, to emphasize the benefits of competitive excellence and the impact of collaborations in defining our distinctive capabilities.
Another guest, Pacific Northwest Laboratory Director William Madia, offered fascinating perspectives on maintaining productivity within the context of dramatically reduced budgets. He described an exhaustive evaluation process at PNL that sought to define priority values for programs and then to reduce spending accordingly. The resulting actions project a savings of $80-110 million from a $280 million baseline of indirect costs.
Although this Laboratory can hope it will not face a similar scenario, current proposals in Congress foretell a more stringent future for us all. Deputy Director Klaus Berkner described his restructuring activities in operations, including a "worst-case" 25-percent indirect cost reduction exercise. I have asked the laboratory's scientific leadership to engage in similar planning scenarios, pending final resolution of our fortunes for the future.
While some time was spent on such sobering topics, most of our work focused on very real prospects for a brighter scientific future at the Laboratory. We reviewed our strategic goals and the actions required to achieve them--full utilization of the Advanced Light Source, continuing growth in the biosciences, development of the Molecular Design Institute, the importance of maintaining our leadership in high energy and nuclear physics, and expansion of our computational sciences program, to name but a few. We discussed the importance of instrumentation and detector science, support for environmental biology, and broadening partnerships with others--for example, in environmental restoration and waste management programs with Pacific Northwest Laboratories, and in genome sequencing with our sister DOE laboratories managed by the University of California.
We revisited our scientific initiatives and talked about how to encourage more cost-effective interdisciplinary program development. We also agreed to establish a Laboratory Scientific Council, through which I can benefit from the advice of our most productive non-management research staff on the quality and performance of our environment.
But most of all, we talked about how we can collectively promote and protect our interests as we proceed through the budget uncertainties ahead. The conversations were free-flowing, direct, sometimes emotional. The participants were all passionate about their people and programs. As we shape our strategic directions in the coming months, we will benefit from such interactions. And so will the Laboratory.
Galtieri explains her topic: "The top quark, the missing building block in the Standard Model of particle physics, has been finally discovered. Physicists have been hunting for it for many years, and the search has been long and difficult. We will discuss what the quarks are, and why the finding of the top quark is so exciting."
In the United States at least, element 106 will henceforth be known as seaborgium, with the chemical symbol of Sg. The American Chemical Society has announced that it is time for all ACS publications to follow the lead of the organization's nomenclature committee and "adopt seaborgium as the official name for element 106." ACS executive director John Crum has also directed the ACS' Publications Division and the Chemical Abstract Service to adopt the names rutherfordium (Rf) for element 104, hahnium (Ha) for 105, nielsborhium (Ns) for 107, hassium (Hs) for 108, and meitnerium (Mt) for 109. Last year, the nomenclature committee of the International Union of Pure and Applied Chemistry had recommended different names for all of these elements, except 109, in a highly controversial action. Last month, IUPAC yielded to the protests and said it would postpone a final decision on the names until 1997. In the face of this indecisiveness, ACS decided to act on its own. All U.S. textbook publishers will be contacted by the ACS and encouraged to use the organization's official names for all of the elements on the periodic table.
LAB LICENSES SOFTWARE:
LBNL has licensed specialized circuit-design software, developed by the Engineering Division's Microelectronics Group, to OEA International Inc., a hi-tech startup company in Silicon Valley. Called PGPSolver, the circuit analysis software is used to calculate inductive parasitics in circuit boards, multichip modules and other electronic assemblies. It was developed by the Microelectronics Group's Mario Aranha and Simon Royer. For more information, contact Engineering's Jacques Millaud (X4169) or Tech Transfer's Viviana Wolinsky (X6463).
YERGIN TASK FORCE ISSUES FINAL REPORT:
The independent Task Force on Strategic Energy Research and Development, commissioned last year by Energy Secretary Hazel O'Leary and chaired by Daniel Yergin, author of "The Prize" and president of the Cambridge Energy Research Associates, made public its conclusions last week. The major message of the Task Force's report, according to Yergin is: "The current scientific and technical base is one of the country's most important assets. But without investment, it cannot be maintained or renewed." The task force said energy R&D is needed "to help mitigate the severe economic risks of possible disruptions in the nation's future energy supplies." The task force did argue that energy R&D must be scrutinized for spending reductions, and recommended that DOE cut 15 percent from research program administrative costs. However, the task force warned that the deep cuts in federal energy R&D now being considered by Congress would "severely damage" existing federal programs and would also hurt private sector R&D through the elimination of many technology transfer efforts. Yergin, whose book traced the history of the oil industry, warned that oil shocks could reappear and that the energy crisis was never really solved. Before the end of the century, he said, oil consumption in Asia will exceed that in the United States. Alternative technologies will be needed and they can only be developed over time. "Innovation and technological creativity cannot be summoned on short notice. It looks to us (the task force) like this is a bad time to cash out our energy R&D investment."
For many college students, a temporary job at LBNL provides a first taste of "real science," and a chance to get a sneak preview of what a career in research involves. But for students such as Jaime Diaz, who works with G. Shyamala Harris in the Life Sciences Division, working at the Laboratory can become much more than a semester-long glimpse into a lab.
Diaz has worked in Shyamala's lab since 1992, while pursuing a major in Integrative Biology and Chicano Studies at UC Berkeley. Shyamala has supported Diaz through supplementary training grants from the National Institutes of Health, which give scientists the resources to bring undergraduate talent into research.
The training has paid off for both student and researcher. Diaz, who just finished his junior year, is now much more than just an extra pair of hands. He is a key contributor to the science coming out of Shyamala's lab, which studies the sex hormones and their relationship to diseases such as breast cancer. His name is on two scientific articles as co-author to prove it.
"It shows that LBNL can nurture intelligent, motivated kids," Shyamala says. "They can come into the lab, learn scientific techniques, and become important members of a team. Taking a student on doesn't have to be like putting a bull in a China shop. Everyone can benefit."
Shyamala thinks that such scientist/student partnerships could help reverse the trend of fewer students pursuing science in graduate school. Infecting students with the "science bug" early on, she says, can be the best way to coax talented undergraduates to go after doctorates in science.
Diaz came to UC Berkeley from East Los Angeles, where he was the first of his family to attend college. He started at LBNL two months into his freshman year, acquiring a position in Shyamala's lab through the financial-aid office on campus.
The job involved mostly run-of-the-mill chores--washing glassware and photocopying articles--but it was an important foot in the laboratory door. "Right away I could see that he had potential," Shyamala said. "I asked him if he wanted to get research training. He said he did."
A supplement to Shyamala's NIH grants allowed Diaz to move from the dish drainer to the lab bench. He began learning immunocytochemistry, which uses antibodies to look at certain molecules inside the cells of a tissue. At the time, Shyamala's group was studying estrogens and their effect on gene expression in mammary tissue development. Diaz learned to remove mammary glands from mice, section the samples, and examine the tissue by antibody analysis.
Shyamala was able to renew Diaz's supplement last fall, and is now training him in molecular biology research. Her group is in the process of creating an animal model for sex hormone research--a transgenic mouse that expresses recombinant genes for progesterone receptors. Diaz has learned to isolate genomic DNA from the mice, and use gene-splicing techniques to determine which of them have taken up the receptor gene.
Diaz says the work at the Lab has given him an edge in science courses down the Hill. "I get to see what I'm learning in textbooks come alive up here," he says.
But it also gives him a different perspective in some of his lab classes. "It seems a little silly sometimes," he said. "My instructors will spend 15 minutes showing the class how to use a pipet--something I have been doing here for three years."
Where Diaz's work experience could really pay off, Shyamala says, is in the workplace after graduation. "Jaime knows how to do so many techniques that your average science undergraduate doesn't," she said. "He could go to any biotech company now and be snatched up immediately. He is much more valuable than the average student."
Diaz sees his future, however, in medicine. He will spend this summer at Tulane University in New Orleans, in a preparatory program for the Medical College Admissions Test. Diaz was one of 30 students selected nationwide for the program. In addition to reviewing for the exams, he will spend the next three months shadowing doctors on their rounds and working on an individual research project.
He will return in August, to continue working at the Laboratory while finishing his senior year at Berkeley. But the research bug may still keep him around after graduation. Says Diaz: "Who knows? I'll still have time left on my supplement. I may end up deferring medical school."
The club welcomes all styles, instruments and abilities. Practices are held at the cafeteria every Tuesday and Thursday from 4 p.m. to 7 p.m. Club meetings are on the second Wednesday of the month at noon in the lower level of the cafeteria. For more information, contact Larry Bell at X5406.
Photos by Mike Wooldridge
The new addition, extending along the hill behind the kitchen, will include two conference rooms, a projection booth, and men's and women's restrooms. A gallery will connect the wing to the current facilities.
The wing will provide approximately 2,000 square feet--the size of the Bldg. 50 Auditorium--of conference space, located conveniently close to catering. The wing should also double as overflow for the cafeteria crowd.
This is not the first time the Lab's cafeteria has grown. The dining room of the original structure, built in 1950, was expanded in 1959. The kitchen was extended and the entryway added in 1965.
The new wing should be complete in February 1996.
26 m o n d a y
WOMEN IN SCIENCE & ENGINEERING SEMINAR
Lina Galtieri of LBNL's Physics Division will discuss "The Discovery of the Top Quark" at 12:15 p.m. in Bldg. 70A-3377; refreshments at noon.
27 t u e s d a y
PHYSICS DIVISION RESEARCH PROGRESS MEETING
"Long Baseline Neutrino Oscillation Experiments at Fermilab" will be presented by S. Wojcicki of Stanford University at 4 p.m. in Bldg. 50A-5132; refreshments at 3:40 p.m.
28 w e d n e s d a y
EH&S CLASS
First Aid (EHS 116), 8 a.m. - noon, Bldg. 48-109; pre-registration required, X6554.
SUMMER LECTURE
Judy Campisi of Life Sciences Division will speak on "Do our Cells have to Age?" at noon in the Bldg. 50 Auditorium.
TOASTMASTERS
Build confidence and develop the ability to effectively organize and present your ideas in a friendly and supportive atmosphere, 12:10 - 1 p.m. in Bldg. 2-100.
29 t h u r s d a y
EH&S CLASS
Adult CPR (EHS 123), 9 a.m. - noon, Bldg. 48-109; pre-registration required, X6554.
GAY PRIDE MONTH
The Laboratory wraps up its recognition of Gay Pride Month with the film "Queer Son," to be shown at noon in the Bldg. 50 Auditorium. The film chronicles the journey of Vicki Seichuk as she attempts to understand her son's sexual orientation and how he expresses it. She interviews other parents and their gay and lesbian children as well.
JOINT CENTER FOR BEAM PHYSICS/ION BEAM TECHNOLOGY PROGRAM SEMINAR
"Microfabrication Using Reactive Ion Etching" will be presented by Dr. I. Rangelow, University of Kassel, Germany at 3:30 p.m. in the Bldg. 71 Conference Room.
PHYSICS DIVISION RESEARCH PROGRESS MEETING
"Recording the `Music' of Excitons: Ultrafast Dynamics of Phase and Amplitude of Coherent Emission by Semiconductor Quantum Wells" will be presented by Daniel Chemla of LBNL at 4 p.m. in Bldg. 50A-5132; refreshments at 3:40 p.m.
30 f r i d a y
ALL SUMMER STUDENTS ARE INVITED TO A PICNIC FROM 11:30 A.M. TO 1 P.M. ON THE FOURTH FLOOR PATIO BETWEEN BLDGS. 2 AND 6.
3 m o n d a y
OPEN CALENDAR
4 t u e s d a y
FOURTH OF JULY HOLIDAY
5 w e d n e s d a y
SUMMER LECTURE SERIES
George Smoot of LBNL's Physics Division will discuss "The Birth of the Universe" at noon in the Bldg. 50 Auditorium.
6 t h u r s d a y
SURFACE/CATALYSIS SCIENCE SEMINAR
"The Oxidation of Nanometer-Thick Silicon and Nickel Films" will be presented by E. Garfunkel of Rutgers University at 1:30 p.m. in the Bldg. 66 Auditorium
7 f r i d a y
CENTER FOR BEAM PHYSICS SEMINAR
"Radiative Cooling of Relativistic Ion Beams and Generation of Intense Gamma Rays Using Laser-Ion Backscattering" will be presented by Dr. Kwang-Je Kim of LBNL at 10:30 a.m. in the Bldg. 71 Conference Room.
Sadie's Early Bird: Fresh banana pancakes w/coffee $2.05
Soup of the Day: Minestrone(TM) reg. $1.35 lg. $1.95
Bistro Fare: Roasted chicken quarters w/potatoes & veggies(TM) $3.95
Passports: South of the Border
Sadie's Grill: Provolone burger w/fries $3.25
tuesday
Sadie's Early Bird: Corned beef hash w/eggs $2.60
Soup of the Day: Hearty vegetable(TM) reg. $1.35 lg. $1.95
Bistro Fare: Zesty stuffed pepper w/pasta & garlic bread $3.95
Passports: South of the Border a la carte
Sadie's Grill: Fishwich w/fries $3.05
wednesday
Sadie's Early Bird: Biscuit & gravy w/eggs $2.60
Soup of the Day: Chicken noodle(TM) reg. $1.35 lg. $1.95
Bistro Fare: Sesame orange pork over rice w/stir fry vegetables $3.95
Passports: South of the Border a la carte
Sadie's Grill: Philly cheese steak w/fries $3.95
thursday
Sadie's Early Bird: Blueberry pancakes w/coffee $2.05
Soup of the Day: Manhattan clam chowder reg. $1.35 lg. $1.95
Bistro Fare: Salad Nicoise(TM) $3.95
Passports: South of the Border
Sadie's Grill: Turkey & Swiss w/fries $3.25
friday
Sadie's Early Bird: Ham scramble $2.60
Soup of the Day: Cream of spinach(TM) reg. $1.35 lg. $1.95
Bistro Fare: Pasta Piatti(TM) $3.95
Sadie's Grill: Chili cheese dog w/fries $3.05
(TM) Denotes recipe lower in fat, calories & cholesterol
Computer users who connect to the Lab from home now have more high-speed options. LBNL's Communications and Networking Resources group has announced ISDN service for remote users (the fastest way to connect to the LBL network from home) and a higher speed ICS line.
ISDN (Integrated Services Digital Network) allows a remote computer to bypass modems and make a direct digital connection to LBL's network. This allows for data speeds of up to 128K baud (high-speed modems typically connect at 14.4K or 28.8K baud). Service for the home requires an ISDN terminal adapter (which costs $600 to $1,600) and an ethernet card. There are also set-up fees and monthly charges to Pacific Bell and LBNL. More information on ISDN is available on the Remote Access Services web page (http://www-cnr/ras/).
The Lab also has a new pool of modems that can support asynchronous connections at speeds up to 19.2K baud. Previous such lines supported connections up to 9.6K baud. The phone number is 486-7992. (Note, not all host systems are capable of supporting 19.2K. Please check with the system administrators for available speeds.)
For more information on remote access, by phone or e-mail, contact CNR's Ed Ritenour (X5754, [email protected]).
AUTOS/SUPPLIES
'70 VOLKSWAGEN Bug convertible, yellow, black top, engine good, left rear fender & rear bumper crunched, runs but will need smog cert. and body work. $1000/b.o. Ken X4745
'79 HONDA Civic CVCC, 4-spd, recently rebuilt, $1500/b.o. Laura, X6325, 458-1217
'82 FORD Club wgn van, 7-pass., 351 cu. in. V-8, 127K mi., blue/white, $3K/b.o. Sergio, X5457, (707) 429-2575
'82 TOYOTA Corolla, 4-dr, 5-spd, a/c, 104K mi., gd cond., $1575. Jim, X6480, 654-1900
'85 HONDA Civic wgn, 8.8K mi., a/t, a/c, AM/FM, pwr steering, gd cond., $2800/b.o., Wei, X5935
`88 FORD Escort LX 1.9l, 110kmi, 4dr, a/c, a/t, cruise control, AM/FM cass, power mirror, gd cond., 3.2K/b.o. Volker X6460, 412-9845
'89 CHEVROLET Celebrity, 88K mi, white, a/t, a/c, exc. cond., clean, $3800. Bjorn, X5173, 524-8021
CARPOOL
RIDER NEEDED for 4 person carpool from Vacaville, Fairfield area, share driving, Mon.-Fri., 7 a.m.-3:30 p.m. work hrs. Mark, X4671, (707)448-7979
WANTED
BIKE, good used hybrid 52 cm (20.5") or sport road bike, 57-59 cm (22.5-23"), Alan Comnes, X4647
PARKING PLACE for 13' travel trailer, prefer nr Berkeley. Phila Rogers, 848-9156
TWIN JOGGING STROLLER, Peter X7653, 530-3044 (eve)
MISCELLANEOUS
BICYCLE, Nishiki, men's 10-spd, exc. cond., extras incl. woman's seat, $125/b.o. 524-1140 (10 a.m.-8 p.m.)
BIKE TRAILER, Burley, '90 model, seats 2 kids, up to 100 lbs., screen cover & rain fly incl., $275. 268-0674
BOAT, aluminum, sm.(12-14') for fishing; car toppable. Bob, 376-2211
BOOKSHELVES, lawyer type, 6'h x 3'w x 14"d, glass-covered shelves, 3 bought for $300 ea, sell for $100 from storage, you pick up. Ken, X4745
CHILD'S BUNK BED, Captain's style, incl. 4-drawer dresser, storage compartments, 1 mattress, OK shape, $75/b.o. Dan, X5139
CAMERA, 35mm SLR, Olympus OM-1; lenses 35mm F2, 100mm F2.8, X2 teleconverter, asst. filters, Gossen light meter, $300. Herb Wellemeyer, 232-0757
CASSETTE DECK, TransAudio 5500, stereo, 15 1/4" W x 5 1/2" H x 10" D, $15. Peter, 531-7837
COMPUTER TABLE, 48"x24", w/hutch, $100; alder table, 16"x48" , $65. F. Robles, X5997
COUCH, Breuner's, green/yellow floral print, quilted/cushioned pillows, 85" long, exc. cond., $250. Lisa, 653-6964
DESK LAMP, black, $5; pen stand, ceramic black, $3; photo album, 100 pg., new, $5; Citronella candles, new, in antiqued glass holders, $3. 843-2097
FISH TANK, 30 gal. complete, fish incl., $50. Pete, X6628
FREEZER, 15 cu. ft. Sears upright, 10 yrs old, works fine, $60. 528-9522
PORTABLE PRINTER, Diconix (Kodak) Model 150, ink-jet printer almost never used, uses tractor-feed paper, $100. John, X7279 or 528-2723.
STEREO SYSTEM, Kenwood, CD, equalizer, amp., double deck, tuner, turntable, glass case, 2 Kenwood 3-way spkrs, $365/b.o. UPS 5500, $90/b.o. X4756, 284-4254.
SAXOPHONE, Selmer Bundy II alto, complete w/mouthpiece and case. Gd pads and looks, dent in bottom, one broken spring (currently fixed with elastic), $430/b.o. Sidnei, X4824 or 649-9242 (eve.)
STITCHER, Commercial blind, Maier, like new, $1300. 932-1398
TENT TRAILER Starcraft, older model, sleeps 8, gd cond., $800/b.o. X4371, 370-6002
TODDLER BED, new, still in box, red metal w/new mattress still in plastic, $60. Teresa, X6246
HOUSING
ALBANY, furn. 1-bdrm apt., w/d, nr UC Village & bus to LBL/UCB, quiet family area, no more than 3 persons, visiting professor with spouse preferred, nonsmokers, avail. immediately, $675/mo. Donald Mangold, X6459
ALBANY, part. furn. 2-bdrm, 2-bth condo, bay view, swimming pool, tennis cts, 24-hr. sec., garage parking, 15 min. bus/BART to LBL/UCB, nr shopping, no pets, non-smoker, lease, $950/mo. 524-7941
ALBANY, Condo for rent, 2 br, 2 bth, spacious, available now. 631-0510
ALBANY, 2 bdrm, unfurn. condo, secured garage, nr BART/EC Plaza, no pets, avail. 8/1/95, $1030/month. Yongyop Kim, 524-4199
BERKELEY, spacious, furn. rm in lg. brn shingle, walk to BART, UC, LBL shuttle & shops, washer/dryer, kitchen privs., non-smoker, short/long term, $400/mo. Rob, 843-5987
NORTH BERKELEY sublet, spacious studio apt w/2 sibling cats, 7/23-8/17, rent neg. in exchg. for cat care. 528-9221.
BERKELEY HILLS house, 3 bdrm, 1 bth, 2 miles from LBL, $1650/mo. 286-7612
NORTH BERKELEY apt. sublet, 7/4 - 8/6, lg. 1 bdrm, garden, nr BART, shopping, $290. Dan, 527-7013
EL CERRITO,1-bdrm,1-bth split-level apt. in duplex, hardwd flr, quiet neighborhood, 8 min walk to BART/EC Plaza, 1/2 blk to bus, $615/mo. 525-7596
OAKLAND, 2-bdrm upstairs apt in brn-shingle house, Grand/Lake area, walk to BART & Piedmont Ave., quiet, non-smoker(s) pref., reasonable utils. incl., $650/mo. 268-0674
OAKLAND HILLS, nr Claremont Hotel, new 1-bdrm in-law apt, balcony, 3-bridge view, hardwd flrs, pvt. entrance, 1-car garage, use of washer/dryer, no smoking, no pets, bicycle to Lab, $875/mo. incl. utils.+dep. 841-6285
PIEDMONT, unfurn. 2-bdrm, 1-bth house, LR, DR, kitchen, garage, garden, laundry, exc. schools, avail. 7/1, $1495/mo. X4190
ROCKRIDGE, furn. bdrm in great 3-bdrm 2-bth apt. nr LBL shuttle, 1 large well-equipped kitchen, laundry, deck, share with 2 grad students, avail. 7/28-8/31, $450. Evan, X4148, 658-7807
WANTED: 2 or 3-bdrm apt/house in Albany for Scandinavian staff sci. & family, prefer 1 yr. lease from 7/1. Bjorn Rydberg, X7045
WANTED: Visiting professor seeks comfortable 1-bdrm apt for 2 people, nr UCB, from beginning of Aug. to mid-Oct. 524-4654
WANTED: house to sit, avail. 7/1, can care for pets, plants, etc., refs upon req. Anne 658-4685
WANTED: Short-term housing for visiting English family, married couple w/2 children, ages 3 & 7, 7/26-8/8/95, pref. nr BART. Mary, X4014, 524-9281
VACATION
NO. TAHOE, 3-bdrm, 2.5 bth home, greenbelt views, lake, beaches, shopping & casinos, within 10 mins., wk/wkend, daily/wkly rates. Wayne Nordby, X7685, 837-2409
TAHOE KEYS, 3-bdrm, 2.5-bth house w/boat dock, mountain view. Bob, 376-2211
REAL ESTATE
HERCULES, townhome, all amenities, asking $128K. 245-8334 eves.
LOST
BERTAN High Voltage Power Supply, model 225-20R (20 kV), last seen in Bldg. 77. Please contact Stephen Trentalange, X5465.
EDITOR:
Mary Bodvarsson, X4014
STAFF WRITERS:
Jeffery Kahn, X4019
Diane LaMacchia, X4015
Mike Wooldridge, X6249
Lynn Yarris, X5375
EDITORIAL ASSISTANT:
Brennan Kreller, X6566
PRODUCTION:
Alice Ramirez
FLEA MARKET/CALENDAR:
Mary Padilla, X5771
Public Information Department
LBNL, MS 65 (Bldg. 65B)
One Cyclotron Rd.
Berkeley, CA 94720
Tel: (510) 486-5771
Fax: (510) 486-6641
LBNL is managed by the
University of California
for the U.S.
Department of Energy